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Endocrine-Related Cancer 5 (1) 27-36    DOI: 10.1677/erc.0.0050027
Copyright © 1998 by the Society for Endocrinology.
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From prolactin cell to prolactinoma: implications of ontogenic mechanisms in diagnosis and management

B Velkeniers 1 and E L Hooghe-Peters 2

1 Endocrinology Unit, University Hospital, Vrije Universiteit Brussel, B-1090 Brussels, Belgium
2 Department of Pharmacology, Faculty of Medicine, Vrije Universiteit Brussel, B-1090 Brussels, Belgium

Today, most patients with hyperprolactinemia are taken care of by endocrinologists, general internists and gynaecologists. With the development of reliable and sensitive hormone assays the introduction of high definition imaging techniques, studies of PRL physiology and gene regulation, the understanding of prolactinoma pathogenesis in humans has progressed at an asthonishing pace over the past twenty years. Clinicians are now relating their clinical findings and therapeutical decisions to this new knowledge related to the pathogenesis and biological behavior of human prolactinomas.






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Copyright © 1998 by the Society for Endocrinology.