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This Article Accepted manuscript (PDF) All Versions of this Article: ERC-09-0184v1 ERC-09-0184v2 17/1/F19    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Boyerinas, B. Articles by Peter, M. E PubMed PubMed Citation Articles by Boyerinas, B. Articles by Peter, M. E

B Boyerinas, The Ben May Department for Cancer Research, The University of Chicago, Chicago, United States
S Park, The Ben May Department for Cancer Research, The University of Chicago, Chicago, United States
A Hau, The Ben May Department for Cancer Research, The University of Chicago, Chicago, United States
A Murmann, The Ben May Department for Cancer Research, The University of Chicago, Chicago, United States
M Peter, The Ben May Department for Cancer Research, The University of Chicago, Chicago, United Kingdom

Correspondence: Marcus E Peter, Email: mpeter{at}uchicago.edu

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression at the translational level. Current evidence suggests that a significant portion of the human genome is regulated by miRNAs, and many reports have demonstrated that miRNA expression is deregulated in human cancer. The let-7 family of miRNAs, first discovered in C. elegans, is functionally conserved from worms to humans. The human let-7 family contains 13 members located on 9 different chromosomes, and many human cancers have deregulated let-7 expression. A growing body of evidence suggests that restoration of let-7 expression may be a useful therapeutic option in cancers where its expression has been lost. In this review, we discuss the role of let-7 in normal development and differentiation and provide an overview of the relationship between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the relationship between let-7 and drug sensitivity are highlighted.

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